Clonidine Hydrochloride
FULL PRESCRIBING INFORMATION: CONTENTS*
- CLONIDINE HYDROCHLORIDE DESCRIPTION
- CLINICAL PHARMACOLOGY
- PHARMACOKINETICS
- INDICATIONS & USAGE
- CLONIDINE HYDROCHLORIDE CONTRAINDICATIONS
- WARNINGS
- PRECAUTIONS
- INFORMATION FOR PATIENTS
- DRUG INTERACTIONS
- TOXICOLOGY
- CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
- PREGNANCY
- NURSING MOTHERS
- PEDIATRIC USE
- CLONIDINE HYDROCHLORIDE ADVERSE REACTIONS
- OVERDOSAGE
- DOSAGE & ADMINISTRATION
- HOW SUPPLIED
- STORAGE AND HANDLING
- PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
FULL PRESCRIBING INFORMATION
CLONIDINE HYDROCHLORIDE DESCRIPTION
CLINICAL PHARMACOLOGY
PHARMACOKINETICS
INDICATIONS & USAGE
CLONIDINE HYDROCHLORIDE CONTRAINDICATIONS
PRECAUTIONS).WARNINGS
WithdrawalBecause children commonly have gastrointestinal illnesses that lead to vomiting, they may be particularly susceptible to hypertensive episodes resulting from abrupt inability to take medication.
PRECAUTIONS
GeneralPerioperative Use
INFORMATION FOR PATIENTS
DRUG INTERACTIONS
Toxicology).
TOXICOLOGY
CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
PREGNANCY
CLINICAL PHARMACOLOGY, Pharmacokinetics). Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
NURSING MOTHERS
PEDIATRIC USE
WARNINGS, Withdrawal).CLONIDINE HYDROCHLORIDE ADVERSE REACTIONS
Body as a Whole:Fatigue, fever, headache, pallor, weakness, and withdrawal syndrome. Also reported were a weakly positive Coombs' test and increased sensitivity to alcohol.
Cardiovascular:Bradycardia, congestive heart failure, electrocardiographic abnormalities (i.e., sinus node arrest, junctional bradycardia, high degree AV block and arrhythmias), orthostatic symptoms, palpitations, Raynaud's phenomenon, syncope, and tachycardia. Cases of sinus bradycardia and atrioventricular block have been reported, both with and without the use of concomitant digitalis.
Central Nervous System:Agitation, anxiety, delirium, delusional perception, hallucinations (including visual and auditory), insomnia, mental depression, nervousness, other behavioral changes, paresthesia, restlessness, sleep disorder, and vivid dreams or nightmares.
Dermatological:Alopecia, angioneurotic edema, hives, pruritus, rash, and urticaria.
Gastrointestinal:Abdominal pain, anorexia, constipation, hepatitis, malaise, mild transient abnormalities in liver function tests, nausea, parotitis, pseudo-obstruction (including colonic pseudo-obstruction), salivary gland pain, and vomiting.
Genitourinary:Decreased sexual activity, difficulty in micturition, erectile dysfunction, loss of libido, nocturia, and urinary retention.
Hematologic:Thrombocytopenia.
Metabolic:Gynecomastia, transient elevation of blood glucose or serum creatine phosphokinase, and weight gain.
Musculoskeletal:Leg cramps and muscle or joint pain.
Oro-otolaryngeal:Dryness of the nasal mucosa.
Ophthalmological:Accommodation disorder, blurred vision, burning of the eyes, decreased lacrimation, and dryness of eyes.
OVERDOSAGE
DOSAGE & ADMINISTRATION
AdultsInitial Dose
Maintenance Dose
Renal Impairment
HOW SUPPLIED
STORAGE AND HANDLING
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
Clonidine Hydrochlorideclonidine hydrochloride TABLET
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PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
