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Baytril Taste Tabs

Bayer HealthCare LLC Animal Health Division

Baytril(enrofloxacin)Taste Tabs Antibacterial Tablets for Dogs and Cats


FULL PRESCRIBING INFORMATION: CONTENTS*




FULL PRESCRIBING INFORMATION

CAUTION:

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Federal law prohibits the extralabel use of this drug in food-producing animals.

BAYTRIL TASTE TABS DESCRIPTION

Enrofloxacin is a synthetic chemotherapeutic agent from the class of the quinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria (See Tables I and II). It is rapidly absorbed from the digestive tract, penetrating into all measured body tissues and fluids (See Table III). Tablets are available in three sizes (22.7, 68.0 and 136.0 mg enrofloxacin).

CHEMICAL NOMENCLATURE AND STRUCTURAL FORMULA:

1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.

Baytril Taste Tabs

ACTIONS:

Microbiology:

Quinolone carboxylic acid derivatives are classified as DNA gyrase inhibitors. The mechanism of action of these compounds is very complex and not yet fully understood. The site of action is bacterial gyrase, a synthesis promoting enzyme. The effect on Escherichia coli is the inhibition of DNA synthesis through prevention of DNA supercoiling. Among other things, such compounds lead to the cessation of cell respiration and division. They may also interrupt bacterial membrane integrity.1

Enrofloxacin is bactericidal, with activity against both Gram negative and Gram positive bacteria. The minimum inhibitory concentrations (MICs) were determined for a series of 39 isolates representing 9 genera of bacteria from natural infections in dogs and cats, selected principally because of resistance to one or more of the following antibiotics: ampicillin, cephalothin, colistin, chloramphenicol, erythromycin, gentamicin, kanamycin, penicillin, streptomycin, tetracycline, triple sulfa and sulfa/trimethoprim. The MIC values for enrofloxacin against these isolates are presented in Table I. Most strains of these organisms were found to be susceptible to enrofloxacin in vitro but the clinical significance has not been determined for some of the isolates.

The susceptibility of organisms to enrofloxacin should be determined using enrofloxacin 5 mcg disks. Specimens for susceptibility testing should be collected prior to the initiation of enrofloxacin therapy.

TABLE I — MIC Values for Enrofloxacin Against Canine and Feline Pathogens(Diagnostic laboratory isolates, 1984)
Organisms Isolates MIC Range
(mcg/mL)
Bacteroides spp. 2 2
Bordetella bronchiseptica 3 0.125-0.5
Brucella canis 2 0.125-0.25
Clostridium perfringens 1 0.5
Escherichia coli 5Includes feline isolates. ≤0.016-0.031
Klebsiella spp. 11Includes feline isolates. 0.031-0.5
Proteus mirabilis 6 0.062-0.125
Pseudomonas aeruginosa 4 0.5-8
Staphylococcus spp. 5 0.125

The inhibitory activity on 120 isolates of seven canine urinary pathogens was also investigated and is listed in Table II.

TABLE II — MIC Values for Enrofloxacin Against Canine Urinary Pathogens (Diagnostic laboratory isolates, 1985)
Organisms Isolates MIC Range
(mcg/mL)
E. coli 30 0.06-2.0
P. mirabilis 20 0.125-2.0
K. pneumoniae 20 0.06-0.5
P. aeruginosa 10 1.0-8.0
Enterobacter spp. 10 0.06-1.0
Staph. (coag. +) 20 0.125-0.5
Strep. (alpha hemol.) 10 0.5-8.0

Distribution in the Body: Enrofloxacin penetrates into all canine and feline tissues and body fluids. Concentrations of drug equal to or greater than the MIC for many pathogens (See Tables I, II and III) are reached in most tissues by two hours after dosing at 2.5 mg/kg and are maintained for 8-12 hours after dosing. Particularly high levels of enrofloxacin are found in urine. A summary of the body fluid/tissue drug levels at 2 to 12 hours after dosing at 2.5 mg/kg is given in Table III.

Table III — Body Fluid/Tissue distribution of Enrofloxacin in Dogs and Cats
Single Oral Dose = 2.5 mg/kg (1.13 mg/lb)

Post-treatment
Enrofloxacin Levels

Canine (n = 2) Feline (n = 4)
Body Fluids (mcg/mL) 2 Hr. 8 Hr. 2 Hr. 12 Hr.
Bile 2.13 1.97
Cerebrospinal Fluid 0.37 0.10
Urine 43.05 55.35 12.81 26.41
Eye Fluids 0.53 0.66 0.45 0.65
Whole Blood 1.01 0.36
Plasma 0.67 0.33
Serum 0.48 0.18
Tissues (mcg/g) Hematopoietic System
Liver 3.02 1.36 1.84 0.37
Spleen 1.45 0.85 1.33 0.52
Bone Marrow 2.10 1.22 1.68 0.64
Lymph Node 1.32 0.91 0.49 0.21
Urogenital System
Kidney 1.87 0.99 1.43 0.37
Bladder Wall 1.36 0.98 1.16 0.55
Testes 1.36 1.10 1.01 0.28
Prostate 1.36 2.20 1.88 0.55
Ovaries 0.78 0.56
Uterine Wall 1.59 0.29 0.81 1.05
Gastrointestinal and Cardiopulmonary Systems
Lung 1.34 0.82 0.91 0.33
Heart 1.88 0.78 0.84 0.32
Stomach 3.24 2.16 3.26 0.27
Small Intestine 2.10 1.11 2.72 0.40
Large Intestine 0.94 1.10
Other
Fat 0.52 0.40 0.24 0.11
Skin 0.66 0.48 0.46 0.17
Muscle 1.62 0.77 0.53 0.29
Brain 0.25 0.24 0.22 0.12
Mammary Gland 0.45 0.21 0.36 0.30
Feces 1.65 9.97 0.37 4.18

Pharmacokinetics:

In dogs, the absorption and elimination characteristics of the oral formulation are linear (plasma concentrations increase proportionally with dose) when enrofloxacin is administered at up to 11.5 mg/kg, twice daily.2 Approximately 80% of the orally administered dose enters the systemic circulation unchanged. The eliminating organs, based on the drug’s body clearance time, can readily remove the drug with no indication that the eliminating mechanisms are saturated. The primary route of excretion is via the urine. The absorption and elimination characteristics beyond this point are unknown. In cats, no oral absorption information is available at other than 2.5 mg/kg, administered orally as a single dose. Saturable absorption and/or elimination processes may occur at greater doses. When saturation of the absorption process occurs, the plasma concentration of the active moiety will be less than predicted, based on the concept of dose proportionality.

Following an oral dose in dogs of 2.5 mg/kg (1.13 mg/lb), enrofloxacin reached 50% of its maximum serum concentration in 15 minutes and peak serum level was reached in one hour. The elimination half-life in dogs is approximately 21/2 - 3 hours at that dose, while in cats it is greater than 4 hours. In a study comparing dogs and cats, the peak concentration and the time to peak concentration were not different.

A graph indicating the mean serum levels following a dose of 2.5 mg/kg (1.13 mg/lb) in dogs (oral and intramuscular) and cats (oral) is shown in Figure 1.

Baytril Taste Tabs
Figure 1 - Serum Concentrations of Enrofloxacin Following a Single Oral or Intramuscular Dose at 2.5 mg/kg in Dogs and a Single Oral Dose at 2.5 mg/kg in Cats.

Breakpoint: Based on pharmacokinetic studies of enrofloxacin in dogs and cats after a single oral administration of 2.5 mg enrofloxacin/kg BW (i.e. half of the lowest-end single daily dose range for dogs and half the single daily dose for cats) and the data listed in Tables I and II, the following breakpoints are recommended for canine and feline isolates.

Zone Diameter (mm) MIC (μg/mL) Interpretation
≥ 21 ≤ 0.5 Susceptible (S)
18 - 20 1 Intermediate (I)
≤ 17 ≥ 2 Resistant (R)

A report of “Susceptible” indicates that the pathogen is likely to be inhibited by generally achievable plasma levels. A report of “Intermediate” is a technical buffer and isolates falling into this category should be retested. Alternatively the organism may be successfully treated if the infection is in a body site where drug is physiologically concentrated. A report of “Resistant” indicates that the achievable drug concentrations are unlikely to be inhibitory and other therapy should be selected.

Standardized procedures require the use of laboratory control organisms for both standardized disk diffusion assays and standardized dilution assays. The 5 μg enrofloxacin disk should give the following zone diameters and enrofloxacin powder should provide the following MIC values for reference strains.

QC strain MIC (μg/mL) Zone
Diameter (mm)
E. coli ATCC 25922 0.008 - 0.03 32 - 40
P. aeruginosa ATCC 27853 1 - 4 15 - 19
S. aureus ATCC 25923 27 - 31
S. aureus ATCC 29213 0.03 - 0.12

INDICATIONS:

Baytril® (brand of enrofloxacin)Taste Tabs® Antibacterial Tablets are indicated for the management of diseases associated with bacteria susceptible to enrofloxacin. Baytril Antibacterial Tablets are indicated for use in dogs and cats.

EFFICACY CONFIRMATION:

Dogs: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus intermedius; respiratory infections (pneumonia, tonsillitis, rhinitis) associated with susceptible strains of Escherichia coli and Staphylococcus aureus; and urinary cystitis associated with susceptible strains of Escherichia coli, Proteus mirabilis, and Staphylococcus aureus.

Palatability: Free choice palatability in dogs was confirmed in a study in which 350 individual dosings resulted in a voluntary ingestion rate of 73%.

Cats: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains of Pasteurella multocida, Staphylococcus aureus, and Staphylococcus epidermidis.

CONTRAINDICATIONS:

Enrofloxacin is contraindicated in dogs and cats known to be hypersensitive to quinolones.

Dogs: Based on the studies discussed under the section on Animal Safety Summary, the use of enrofloxacin is contraindicated in small and medium breeds of dogs during the rapid growth phase (between 2 and 8 months of age). The safe use of enrofloxacin has not been established in large and giant breeds during the rapid growth phase. Large breeds may be in this phase for up to one year of age and the giant breeds for up to 18 months. In clinical field trials utilizing a daily oral dose of 5.0 mg/kg, there were no reports of lameness or joint problems in any breed. However, controlled studies with histological examination of the articular cartilage have not been conducted in the large or giant breeds.

ADVERSE REACTIONS:

Dogs: Two of the 270 (0.7%) dogs treated with Baytril® (brand of enrofloxacin) Tablets at 5.0 mg/kg per day in the clinical field studies exhibited side effects, which were apparently drug-related. These two cases of vomition were self-limiting.

Post-Approval Experience: The following adverse experiences, although rare, are based on voluntary post-approval adverse drug experience reporting. The categories of reactions are listed in decreasing order of frequency by body system.

Gastrointestinal: anorexia, diarrhea, vomiting, elevated liver enzymes

Neurologic: ataxia, seizures

Behavioral: depression, lethargy, nervousness

Cats: No drug-related side effects were reported in 124 cats treated with Baytril® (brand of enrofloxacin) Tablets at 5.0 mg/kg per day for 10 days in clinical field studies.

Post-Approval Experience: The following adverse experiences, although rare, are based on voluntary post-approval adverse drug experience reporting. The categories of reactions are listed in decreasing order of frequency by body system.

Ocular: Mydriasis, retinal degeneration (retinal atrophy, attenuated retinal vessels, and hyperreflective tapeta have been reported), loss of vision. Mydriasis may be an indication of impending or existing retinal changes.

Gastrointestinal: vomiting, anorexia, elevated liver enzymes, diarrhea

Neurologic: ataxia, seizures

Behavioral: depression, lethargy, vocalization, aggression

To report adverse reactions, call 1-800-422-9874.

Dogs: Adult dogs receiving enrofloxacin orally at a daily dosage rate of 52 mg/kg for 13 weeks had only isolated incidences of vomition and inappetence. Adult dogs receiving the tablet formulation for 30 consecutive days at a daily treatment of 25 mg/kg did not exhibit significant clinical signs nor were there effects upon the clinical chemistry, hematological or histological parameters. Daily doses of 125 mg/kg for up to 11 days induced vomition, inappetence, depression, difficult locomotion and death while adult dogs receiving 50 mg/kg/day for 14 days had clinical signs of vomition and inappetence.

Adult dogs dosed intramuscularly for three treatments at 12.5 mg/kg followed by 57 oral treatments at 12.5 mg/kg, all at 12 hour intervals, did not exhibit either significant clinical signs or effects upon the clinical chemistry, hematological or histological parameters.

Oral treatment of 15 to 28 week old growing puppies with daily dosage rates of 25 mg/kg has induced abnormal carriage of the carpal joint and weakness in the hindquarters.

Significant improvement of clinical signs is observed following drug withdrawal. Microscopic studies have identified lesions of the articular cartilage following 30 day treatments at either 5, 15 or 25 mg/kg in this age group. Clinical signs of difficult ambulation or associated cartilage lesions have not been observed in 29 to 34 week old puppies following daily treatments of 25 mg/kg for 30 consecutive days nor in 2 week old puppies with the same treatment schedule.

Tests indicated no effect on circulating microfilariae or adult heartworms (Dirofilaria immitis) when dogs were treated at a daily dosage rate of 15 mg/kg for 30 days. No effect on cholinesterase values was observed.

No adverse effects were observed on reproductive parameters when male dogs received 10 consecutive daily treatments of 15 mg/kg/day at 3 intervals (90, 45 and 14 days) prior to breeding or when female dogs received 10 consecutive daily treatments of 15 mg/kg/day at 4 intervals: between 30 and 0 days prior to breeding, early pregnancy (between 10th & 30th days), late pregnancy (between 40th & 60th days), and during lactation (the first 28 days).

Cats: Cats in age ranges of 3 to 4 months and 7 to 10 months received daily treatments of 25 mg/kg for 30 consecutive days with no adverse effects upon the clinical chemistry, hematological or histological parameters. In cats 7-10 months of age treated daily for 30 consecutive days, 2 of 4 receiving 5 mg/kg, 3 of 4 receiving 15 mg/kg, 2 of 4 receiving 25 mg/kg and 1 of 4 nontreated controls experienced occasional vomition. Five to 7 month old cats had no side effects with daily treatments of 15 mg/kg for 30 days, but 2 of 4 animals had articular cartilage lesions when administered 25 mg/kg per day for 30 days.

Doses of 125 mg/kg for 5 consecutive days to adult cats induced vomition, depression, incoordination and death while those receiving 50 mg/kg for 6 days had clinical signs of vomition, inappetence, incoordination and convulsions, but they returned to normal.

Enrofloxacin was administered to thirty-two (8 per group), six- to eight-month-old cats at doses of 0, 5, 20, and 50 mg/kg of body weight once a day for 21 consecutive days. There were no adverse effects observed in cats that received 5 mg/kg body weight of enrofloxacin. The administration of enrofloxacin at 20 mg/kg body weight or greater caused salivation, vomition, and depression. Additionally, dosing at 20 mg/kg body weight or greater resulted in mild to severe fundic lesions on ophthalmologic examination (change in color of the fundus, central or generalized retinal degeneration), abnormal electroretinograms (including blindness), and diffuse light microscopic changes in the retina.

DRUG INTERACTIONS:

Compounds that contain metal cations (e.g., aluminum, calcium, iron, magnesium) may reduce the absorption of some quinolone-class drugs from the intestinal tract. Concomitant therapy with other drugs that are metabolized in the liver may reduce the clearance rates of the quinolone and the other drug.

Dogs: Enrofloxacin has been administered to dogs at a daily dosage rate of 10 mg/kg concurrently with a wide variety of other health products including anthelmintics (praziquantel, febantel, sodium disophenol), insecticides (fenthion, pyrethrins), heartworm preventatives (diethylcarbamazine) and other antibiotics (ampicillin, gentamicin sulfate, penicillin, dihydrostreptomycin). No incompatibilities with other drugs are known at this time.

Cats: Enrofloxacin was administered at a daily dosage rate of 5 mg/kg concurrently with anthelmintics (praziquantel, febantel), an insecticide (propoxur) and another antibacterial (ampicillin). No incompatibilities with other drugs are known at this time.

WARNINGS:

For use in animals only. In rare instances, use of this product in cats has been associated with Retinal Toxicity. Do not exceed 5 mg/kg of body weight per day in cats. Safety in breeding or pregnant cats has not been established. Keep out of reach of children.

Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water.

Consult a physician if irritation persists following ocular or dermal exposure. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight.

For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-633-3796.

Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.

Quinolone-class drugs have been associated with cartilage erosions in weight-bearing joints and other forms of arthropathy in immature animals of various species.

The use of fluoroquinolones in cats has been reported to adversely affect the retina. Such products should be used with caution in cats.

Dogs: Administer orally at a rate to provide 5-20 mg/kg (2.27 to 9.07 mg/lb) of body weight. Selection of a dose within the range should be based on clinical experience, the severity of disease, and susceptibility of the pathogen. Animals which receive doses in the upper-end of the dose range should be carefully monitored for clinical signs that may include inappetance, depression, and vomition.

All tablet sizes are double scored for accurate dosing.
Weight
of Dog
Once Daily Dosing Chart
5.0 mg/kg 10.0 mg/kg 15.0 mg/kg 20.0 mg/kg
9.1 kg
(20 lb)
2 x 22.7 mg
tablets
1 x 22.7 mg plus
1 x 68 mg tablets
1 x 136 mg
tablet
1 x 136 mg plus
2 x 22.7 mg tablets
27.2 kg
(60 lb)
1 x 136 mg
tablet
2 x 136 mg
tablets
3 x 136 mg
tablets
4 x 136 mg
tablets

Cats: Administer orally at 5 mg/kg (2.27 mg/lb) of body weight. The dose for dogs and cats may be administered either as a single daily dose or divided into two (2) equal daily doses administered at twelve (12) hour intervals. The dose should be continued for at least 2-3 days beyond cessation of clinical signs, to a maximum of 30 days.

All tablet sizes are double scored for accurate dosing.
Weight
of Cat
Once Daily Dosing Chart
(5 mg/kg/day)
5 lb
(2.27 kg)
1/2 x 22.7 mg tablet
10 lb
(4.5 kg)
1 x 22.7 mg tablet
15 lb
(6.8 kg)
1 and 1/2 x 22.7 mg tablets or
1/2 x 68 mg tablet

Palatability: Most dogs will consume Baytril® Taste Tabs® Tablets willingly when offered by hand. Alternatively the tablet(s) may be offered in food or hand-administered (pilled) as with other oral tablet medications. In cats, Baytril® Taste Tabs® Tablets should be pilled. After administration, watch the animal closely to be certain the entire dose has been consumed.

Dogs & Cats: The duration of treatment should be selected based on clinical evidence.

Generally, administration of Baytril Tablets should continue for at least 2-3 days beyond cessation of clinical signs. For severe and/or complicated infections, more prolonged therapy, up to 30 days, may be required. If no improvement is seen within five days, the diagnosis should be reevaluated and a different course of therapy considered.

The lower limit of the dose range in dogs and the daily dose for cats was based on efficacy studies in dogs and cats where enrofloxacin was administered at 2.5 mg/kg twice daily. Target animal safety and toxicology were used to establish the upper limit of the dose range for dogs and treatment duration for dogs and cats.

STORAGE:

Dispense tablets in tight containers only. Baytril Taste Tablets should be stored at or below 77° F (25° C).

HOW SUPPLIED:

Taste Tabs®
Code No.
Film Coated
Code No.
Baytril Tablets
Tablet Size
Tablets/Bottle
08711367 08713262 22.7 mg 100 Double Scored
08711375 08713289 22.7 mg 500 Double Scored
08711383 08713270 68.0 mg 50 Double Scored
08711391 08713297 68.0 mg 250 Double Scored
08711510 136.0 mg 50 Double Scored
08711405 136.0 mg 200 Double Scored

Bayer, the Bayer Cross and Baytril are registered trademarks of Bayer.

REFERENCES:

  • Doughherty, T.J., & Saukkonen, J.J. (1985). Membrane permeability changes associated with DNA gyrase inhibitors in Escherichia Coli.  Antimicrob Agents Chemother, 28 (2), 200-206.
  • Walker, R.D., Stein, G.E., Hauptmam, J.G., McDonald, K.H. (1992). Pharmacokinetic evaluation of enrofloxacin administered orally to healthy dogs.  Am J Vet Res, 53 (12):2315-2319.

Bayer HealthCare LLC
Animal Health Division

Shawnee Mission, Kansas 66201 U.S.A.

08714684-71003870, R.12

©2011 Bayer HealthCare LLC                            February, 2011
15753

Principal Display Panels - 22.7 mg 500 Taste Tabs

Baytril Taste Tabs

Principal Display Panels - 22.7 mg 100 Taste Tabs

Baytril Taste Tabs

Principal Display Panels - 68 mg 50 Taste Tabs

Baytril Taste Tabs

Principal Display Panels- 68mg 250 Taste Tabs

Baytril Taste Tabs

Principal Display Panels - 136mg 50 Taste Tabs

Baytril Taste Tabs

Principal Display Panels - 136 mg 200 Taste Tabs

Baytril Taste Tabs

Baytril Taste Tabs

enrofloxacin TABLET, CHEWABLE

Product Information

Product Type Prescription animal drug label Item Code (Source) NDC:0859-2168
Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety

Ingredient Name Basis of Strength Strength
ENROFLOXACIN ENROFLOXACIN 22.7 mg

Product Characteristics

Color Size Imprint Code Shape
BROWN 10 mm B23 ROUND

Packaging

# Item Code Package Description Marketing Start Date Marketing End Date
1 NDC:0859-2168-01 100 in 1 BOTTLE
2 NDC:0859-2168-02 500 in 1 BOTTLE

Marketing Information

Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NADA NADA140441 1988-12-27


Baytril Taste Tabs

enrofloxacin TABLET, CHEWABLE

Product Information

Product Type Prescription animal drug label Item Code (Source) NDC:0859-2169
Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety

Ingredient Name Basis of Strength Strength
ENROFLOXACIN ENROFLOXACIN 68 mg

Product Characteristics

Color Size Imprint Code Shape
BROWN 14 mm B68 ROUND

Packaging

# Item Code Package Description Marketing Start Date Marketing End Date
1 NDC:0859-2169-01 50 in 1 BOTTLE
2 NDC:0859-2169-02 250 in 1 BOTTLE

Marketing Information

Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NADA NADA140441 1988-12-27


Baytril Taste Tabs

enrofloxacin TABLET, CHEWABLE

Product Information

Product Type Prescription animal drug label Item Code (Source) NDC:0859-2167
Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety

Ingredient Name Basis of Strength Strength
ENROFLOXACIN ENROFLOXACIN 136 mg

Product Characteristics

Color Size Imprint Code Shape
BROWN 16 mm B136 ROUND

Packaging

# Item Code Package Description Marketing Start Date Marketing End Date
1 NDC:0859-2167-01 50 in 1 BOTTLE
2 NDC:0859-2167-02 200 in 1 BOTTLE

Marketing Information

Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NADA NADA140441 1988-12-27


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